A once-discarded approach to radiation therapy for brain tumors has re-emerged as a solid secondary treatment for refractory disease. Surgically targeted radiation therapy (STaRT),a form of Cesium-131 brachytherapy, is now used in cases of recurrent glioblastomas (GBM), other high-grade gliomas, high-grade meningiomas, and brain metastases. Cleveland Clinic’s Weston Hospital is one of a handful of centers in Florida, and the first across the Cleveland Clinic enterprise, to offer STaRT.